Description

Sn-38-D3 is a deuterated analog of the potent topoisomerase I inhibitor SN-38, which is the active metabolite of the chemotherapeutic prodrug Irinotecan. This compound is of significant value as a stable isotope-labeled internal standard for quantitative bioanalytical assays in pharmaceutical research and development. It is primarily required by analytical laboratories, CROs, and pharmaceutical companies engaged in the precise quantification of SN-38 and Irinotecan in biological matrices for pharmacokinetic, metabolic, and toxicological studies.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering internal standard for the accurate quantification of SN-38 and Irinotecan in plasma, serum, and tissue samples using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
• Drug Metabolism and Pharmacokinetics (DMPK): Enables precise tracking of the parent drug's absorption, distribution, metabolism, and excretion (ADME) profile in preclinical and clinical studies.
• Bioanalytical Method Development and Validation: Used as a reference material to develop, optimize, and validate robust, GLP-compliant analytical methods.
• Clinical Trial Support: Provides essential data integrity for bioanalysis in oncology clinical trials involving Irinotecan-based therapies.
• Metabolite Profiling: Aids in the identification and quantification of drug metabolites in complex biological systems.
• Quality Control in Manufacturing: Can be utilized in quality control laboratories to monitor process-related impurities or for assay development of the active pharmaceutical ingredient (API).

Basic Information

Product Name	Sn-38-D3
CAS No.	718612-49-8
Molecular Formula	C22H17D3N2O5
Molecular Weight	395.41 g/mol
Synonyms	7-Ethyl-10-hydroxycamptothecin-d3; SN-38-d3; (S)-10-Hydroxy-7-ethyl-20(S)-camptothecin-d3; Irinotecan metabolite D3; CPT-11 active metabolite D3; Deuterated SN-38; 7-Ethyl-10-hydroxycamptothecin (deuterated); 10-Hydroxy-7-ethylcamptothecin-d3
EINECS	Contact for details

Quality Control

Our Sn-38-D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chemical and isotopic purity, NMR and MS for structural confirmation, and determination of residual solvents and moisture content. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with research and method validation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled, dry environment to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 99.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.