Description

Benzenethiol, 2-(Aminomethyl)-5-Fluoro- (9Ci) is a specialized aromatic thiol derivative featuring both an aminomethyl and a fluorine substituent, making it a valuable bifunctional building block. This compound is significant for its dual reactivity, offering sites for nucleophilic thiol chemistry and amine-based conjugation or modification. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for synthesizing novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, where the fluorine atom enhances biological activity and metabolic stability.
• Peptide Mimetics & Conjugation: The thiol and amine groups enable its use in creating peptide analogs or for site-specific bioconjugation (e.g., antibody-drug linker chemistry).
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and functional surfaces.
• Ligand Synthesis for Catalysis: Employed in the preparation of novel chelating ligands for metal catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Useful for creating activity-based probes to study enzyme function, leveraging the reactive thiol group.

Basic Information

Product Name	Benzenethiol, 2-(Aminomethyl)-5-Fluoro- (9Ci)
CAS No.	717092-78-9
Molecular Formula	C7H8FNS
Molecular Weight	157.21 g/mol
Synonyms	5-Fluoro-2-(aminomethyl)benzenethiol; 2-(Aminomethyl)-5-fluorobenzenethiol; 5-Fluoro-2-mercaptobenzylamine; 2-Aminomethyl-5-fluorothiophenol; (5-Fluoro-2-mercaptophenyl)methanamine; 2-Fluoro-5-(aminomethyl)thiophenol; 717092-78-9 (CAS); 5-Fluoro-2-thiobenzylamine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with a typical purity of ≥97% (by HPLC), suitable for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. For custom purity grades or specific pharmacopeial standards (e.g., USP, EP), please contact our technical sales team.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. This material is light-sensitive and easily oxidized; prolonged exposure to air or light should be avoided.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.