Description

n-{(Z)-3,4-Dihydroisoquinolin-2(1H)-Yl[(4,6-Dimethylpyrimidin-2-Yl)Amino]Methylidene}-2,2,2-Trifluoroacetamide is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure incorporating dihydroisoquinoline and dimethylpyrimidine moieties. This compound is essential for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Process Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Research & Manufacturing (CRAM): Supplied to organizations providing outsourced drug development and manufacturing services.
• Academic Research: Utilized in university and institutional labs for investigating novel heterocyclic chemistry and reaction methodologies.
• Pre-clinical Development: Incorporated into compounds being evaluated for pharmacokinetics, toxicology, and efficacy in pre-clinical studies.

Basic Information

Product Name	n-{(Z)-3,4-Dihydroisoquinolin-2(1H)-Yl[(4,6-Dimethylpyrimidin-2-Yl)Amino]Methylidene}-2,2,2-Trifluoroacetamide
CAS No.	714244-99-2
Molecular Formula	C₁₈H₁₈F₃N₅O
Molecular Weight	377.37 g/mol
Synonyms	2,2,2-Trifluoro-N-[(Z)-[(2,3-dihydro-1H-isoquinolin-2-yl)(4,6-dimethylpyrimidin-2-ylamino)methylene]acetamide; N-[(Z)-[2,3-Dihydro-1H-isoquinolin-2-yl(4,6-dimethylpyrimidin-2-ylamino)methylene]-2,2,2-trifluoroacetamide; (Z)-N-((2,3-Dihydro-1H-isoquinolin-2-yl)((4,6-dimethylpyrimidin-2-yl)amino)methylene)-2,2,2-trifluoroacetamide; CAS 714244-99-2; Trifluoroacetamide derivative of dihydroisoquinoline-pyrimidine; Dihydroisoquinoline-pyrimidine trifluoroacetamide intermediate
EINECS	Contact for details

Quality Control

Our n-{(Z)-3,4-Dihydroisoquinolin-2(1H)-Yl[(4,6-Dimethylpyrimidin-2-Yl)Amino]Methylidene}-2,2,2-Trifluoroacetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation, and impurity profile is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is sensitive to light and strong alkali/fluoride conditions; ensure proper handling and segregation from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Any single unknown impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.