Description

L-Dopa-2,5,6,α,β,β-D6 is a stable isotope-labeled analog of L-Dopa, a critical precursor in dopamine biosynthesis. This high-purity deuterated compound is essential for advanced analytical and research applications requiring precise internal standards and metabolic pathway tracing. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in neurochemical research, pharmacokinetic studies, and the development of diagnostic assays.

Application

• Internal Standard for Mass Spectrometry: Serves as a critical quantitative reference in LC-MS/MS and GC-MS analysis of L-Dopa and its metabolites in biological matrices.
• Pharmacokinetic and Metabolic Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Neurochemical Research: Used in studies investigating dopamine synthesis, regulation, and related neurological disorders such as Parkinson's disease.
• Diagnostic Assay Development: Employed in the calibration and validation of high-sensitivity clinical diagnostic tests for neurotransmitter levels.
• Isotope Dilution Analysis: Provides accuracy and precision in quantitative analysis where non-labeled compounds may interfere.
• Quality Control in Pharmaceutical Manufacturing: Supports analytical method development and verification for drug substance and product testing.

Basic Information

Product Name	L-Dopa-2,5,6,α,β,β-D6
CAS No.	713140-75-1
Molecular Formula	C9H5D6NO4
Molecular Weight	203.22 g/mol
Synonyms	(2S)-2-Amino-3-(3,4-dihydroxyphenyl)-2,5,6,α,β,β-d6-propanoic acid; Levodopa-d6; L-3,4-Dihydroxyphenylalanine-2,5,6,α,β,β-d6; L-DOPA-d6; (-)-Dopa-d6; (S)-2-Amino-3-(3,4-dihydroxyphenyl)propionic-2,5,6,α,β,β-d6 acid; 3-Hydroxy-L-tyrosine-d6
EINECS	Contact for details

Quality Control

Our L-Dopa-2,5,6,α,β,β-D6 is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and impurity profiles. We adhere to relevant industry guidelines for stable isotope-labeled compounds to ensure reliable performance as an internal standard.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥98 atom % D
Chemical Purity (HPLC)	≥95.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.