Description

3-Iodothyronamine-[Ethylamino-1,1,2,2-2H4] Hydrochloride is a high-purity, deuterium-labeled derivative of the endogenous signaling molecule 3-iodothyronamine (T1AM). This compound is specifically designed for use as a critical internal standard in quantitative bioanalytical research, ensuring unparalleled accuracy in mass spectrometry-based assays. It is an essential tool for researchers and pharmaceutical developers in the fields of endocrinology, neuropharmacology, and metabolic disease research, where precise measurement of trace-level endogenous compounds is required.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a stable isotope-labeled internal standard for the accurate quantification of endogenous 3-iodothyronamine (T1AM) and related metabolites in complex biological matrices such as plasma, serum, and tissue homogenates.
• Pharmacokinetic and Pharmacodynamic (PK/PD) Studies: Enables precise tracking of T1AM dynamics in preclinical and clinical research, facilitating studies on its metabolism, distribution, and mechanism of action.
• Endocrinology and Metabolic Research: Used in investigations of trace amine-associated receptors (TAARs), particularly TAAR1, to elucidate the role of T1AM in metabolic regulation, thermogenesis, and cardiac function.
• Neuropharmacology: Supports research into the neuromodulatory effects of thyronamines, including studies on sleep, mood, and cognitive function.
• Method Development and Validation: Critical for developing, optimizing, and validating robust analytical methods in compliance with guidelines from regulatory bodies like the FDA and EMA.
• Biomarker Discovery and Validation: Aids in the identification and validation of T1AM as a potential biomarker for thyroid function disorders and metabolic syndromes.

Basic Information

Product Name	3-Iodothyronamine-[Ethylamino-1,1,2,2-2H4] Hydrochloride
CAS No.	712349-95-6
Molecular Formula	C11H11D4IN2O3 • HCl
Molecular Weight	414.63 g/mol (for free base C11H15IN2O3)
Synonyms	Deuterated 3-Iodothyronamine Hydrochloride; [2H4]-3-T1AM Hydrochloride; 3-Iodo-thyronamine-d4 HCl; 3-Iodothyronamine (ethylamino-d4) hydrochloride; T1AM-d4 HCl; 3-IT1AM-d4; (4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl)ethanamine-d4 hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 3-Iodothyronamine-[Ethylamino-1,1,2,2-2H4] Hydrochloride is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. Our rigorous quality testing ensures high chemical purity, isotopic enrichment, and structural integrity, meeting the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity (HPLC), isotopic purity (MS), and identification data (NMR, IR) is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity	≥ 98 atom % D
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.