Description

(1R,2R,3S,5R)-2-Amino-2,6,6-Trimethyl-Bicyclo[3.1.1]Heptane-3-Carboxylic Acid Methyl Ester Hydrochloride is a high-purity, stereochemically defined chiral building block and pharmaceutical intermediate. This compound is critical for the synthesis of complex molecules where precise spatial orientation of functional groups dictates biological activity and efficacy. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and fine chemical industries for developing novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring rigid, bicyclic scaffolds.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new drug candidates, especially those targeting neurological and metabolic disorders.
• Asymmetric Synthesis: Serves as a versatile precursor in stereoselective chemical reactions to construct complex molecular architectures.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its constrained bicyclic framework.
• Peptidomimetics Development: Acts as a non-natural amino acid analog to create protease-resistant or conformationally restricted peptide-like molecules.
• Reference Standard: Employed as an analytical standard for quality control and method validation in API manufacturing.
• Chemical Biology Probes: Utilized in the design of molecular probes to study enzyme mechanisms or protein-ligand interactions.

Basic Information

Product Name	(1R,2R,3S,5R)-2-Amino-2,6,6-Trimethyl-Bicyclo[3.1.1]Heptane-3-Carboxylic Acid Methyl Ester Hydrochloride
CAS No.	705949-01-5
Molecular Formula	C13H24ClNO2
Molecular Weight	261.79 g/mol
Synonyms	(-)-2-Amino-2,6,6-trimethylbicyclo[3.1.1]heptane-3-carboxylic acid methyl ester hydrochloride; (1R,2R,3S,5R)-2-Amino-2,6,6-trimethylbicyclo[3.1.1]heptane-3-carboxylic acid methyl ester HCl; Methyl (1R,2R,3S,5R)-2-amino-2,6,6-trimethylbicyclo[3.1.1]heptane-3-carboxylate hydrochloride; Pinane amino acid ester hydrochloride; Bicyclo[3.1.1]heptane-3-carboxylic acid, 2-amino-2,6,6-trimethyl-, methyl ester, hydrochloride, (1R,2R,3S,5R)-
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, and chiral analysis to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.