Description

5(1H)-Indolizinone,2,3,8,8A-Tetrahydro-8-Hydroxy-8-Methyl-,(8S,8As)-(9Ci) is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is valued for its role as a critical building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents. Our supply ensures consistent quality and reliable availability for your most demanding R&D and scale-up projects.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to explore new chemical entities.
• Asymmetric Synthesis: Utilized as a precursor or scaffold in catalytic asymmetric reactions to construct complex molecular architectures with high enantiomeric purity.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Employed in university and institutional labs for methodological development in organic synthesis and heterocyclic chemistry.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in API manufacturing.

Basic Information

Product Name	5(1H)-Indolizinone,2,3,8,8A-Tetrahydro-8-Hydroxy-8-Methyl-,(8S,8As)-(9Ci)
CAS No.	705927-10-2
Molecular Formula	C9H13NO2
Molecular Weight	167.21 g/mol
Synonyms	(8S,8aR)-2,3,8,8a-Tetrahydro-8-hydroxy-8-methyl-5H-indolizin-5-one; (8S,8aR)-8-Hydroxy-8-methyl-2,3,8,8a-tetrahydro-5H-indolizin-5-one; 8-Hydroxy-8-methyl-2,3,8,8a-tetrahydro-5H-indolizin-5-one (8S,8aR)-; 705927-10-2; 5H-Indolizin-5-one, 2,3,8,8a-tetrahydro-8-hydroxy-8-methyl-, (8S,8aR)-; (8S,8aR)-8-Methyl-8-hydroxy-2,3,8,8a-tetrahydro-5H-indolizin-5-one
EINECS	Contact for details

Quality Control

Our 5(1H)-Indolizinone,2,3,8,8A-Tetrahydro-8-Hydroxy-8-Methyl-,(8S,8As)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral assay, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We can support development with custom purity grades and analytical method data.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storage under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.