Description

(2S,3S)-2-Amino-3-(4-Fluorophenyl)-1-(Thiazolidin-3-Yl)Butan-1-One is a high-purity chiral building block featuring a thiazolidine scaffold and a fluorinated aromatic group. This compound is critical for pharmaceutical research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting neurological and metabolic disorders. It is primarily utilized by medicinal chemists and process development scientists in pharmaceutical and biotechnology companies for lead optimization and the creation of proprietary drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug molecules, especially those requiring a fluorinated phenylalanine derivative.
• Protease Inhibitor Research: Serves as a core structural component in the development of inhibitors for various protease enzymes.
• Peptidomimetic Chemistry: Used to construct non-peptide scaffolds that mimic the structure and function of natural peptides, enhancing metabolic stability.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in stereoselective chemical transformations to introduce specific chiral centers.
• Library Synthesis for Drug Discovery: A valuable building block for generating focused combinatorial libraries to screen for new biological activity.

Basic Information

Product Name	(2S,3S)-2-Amino-3-(4-Fluorophenyl)-1-(Thiazolidin-3-Yl)Butan-1-One
CAS No.	705292-59-7
Molecular Formula	C₁₃H₁₇FN₂OS
Molecular Weight	268.35 g/mol
Synonyms	(2S,3S)-2-Amino-3-(4-fluorophenyl)-1-(thiazolidin-3-yl)butan-1-one; 3-[(2S,3S)-2-Amino-3-(4-fluorophenyl)butanoyl]thiazolidine; (2S,3S)-2-Amino-3-(p-fluorophenyl)-1-(thiazolidin-3-yl)-1-butanone; Thiazolidine, 3-[(2S,3S)-2-amino-3-(4-fluorophenyl)-1-oxobutyl]-; CAS 705292-59-7; Fluorinated thiazolidine amino ketone; (S,S)-Amino fluoro phenyl thiazolidinyl butanone
EINECS	Contact for details

Quality Control

Every batch of (2S,3S)-2-Amino-3-(4-Fluorophenyl)-1-(Thiazolidin-3-Yl)Butan-1-One is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for advanced research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.