Description

1-(6-Bromo-1H-Indol-3-Yl)-2,2,2-Trifluoroethanone is a high-purity, advanced pharmaceutical intermediate featuring a brominated indole core and a reactive trifluoroacetyl group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel bioactive molecules. It is primarily sought by R&D laboratories and manufacturers in the pharmaceutical and agrochemical sectors for creating new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those targeting neurological and oncological pathways.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and high-throughput screening libraries.
• Agrochemical Development: Serves as a building block for novel pesticides and herbicides due to its halogenated structure.
• Fluorinated Compound Synthesis: The trifluoroacetyl moiety is utilized to introduce fluorine atoms, enhancing metabolic stability and lipophilicity in target compounds.
• Chemical Biology Probes: Employed in the development of molecular probes for studying enzyme function and protein interactions.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers and advanced organic materials.

Basic Information

Item	Detail
Product Name	1-(6-Bromo-1H-Indol-3-Yl)-2,2,2-Trifluoroethanone
CAS No.	79878-02-7
Molecular Formula	C10H5BrF3NO
Molecular Weight	292.05 g/mol
Synonyms	6-Bromo-3-trifluoroacetylindole; 1-(6-Bromo-1H-indol-3-yl)-2,2,2-trifluoroethanone; 6-Bromo-3-trifluoroacetylinodole; 6-Bromoindole-3-carboxylic acid trifluoromethyl ketone; 3-Trifluoroacetyl-6-bromoindole; 6-Bromo-1H-indole-3-yl trifluoromethyl ketone; 79878-02-7; 6-Bromo-α,α,α-trifluoro-1H-indole-3-acetophenone
EINECS	Contact for details

Quality Control

Our 1-(6-Bromo-1H-Indol-3-Yl)-2,2,2-Trifluoroethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is sensitive to strong alkalis and fluorides; keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.