Description

(S)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid Methyl Ester is a high-value chiral building block and intermediate of significant importance in modern organic synthesis. Its core value lies in its stereochemically defined isoquinoline scaffold, which is a privileged structure in medicinal chemistry for constructing bioactive molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel drug candidates and fine chemicals requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potential therapeutic agents, including enzyme inhibitors, receptor modulators, and central nervous system (CNS) active compounds.
• Asymmetric Synthesis: Used as a starting material or intermediate in catalytic asymmetric reactions to construct complex molecules with high enantiomeric purity.
• Medicinal Chemistry Research: Serves as a core scaffold for constructing libraries of compounds in structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Agrochemical Development: Employed in the research and synthesis of novel, chiral active ingredients for crop protection products.
• Fine Chemical Production: Utilized in the custom synthesis of specialty chemicals, advanced materials, and other high-value chiral products.
• Academic & Institutional Research: A valuable reagent for methodological development in organic chemistry and for studying reaction mechanisms involving nitrogen-containing heterocycles.

Basic Information

Product Name	(S)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid Methyl Ester
CAS No.	79799-05-6
Molecular Formula	C11H13NO2
Molecular Weight	191.23 g/mol
Synonyms	(S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid methyl ester; Methyl (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate; (S)-Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate; (S)-Tic-OMe; (S)-TIQ-3-COOMe; (S)-3-Methoxycarbonyl-1,2,3,4-tetrahydroisoquinoline; L-Tic-OMe
EINECS	Contact for details

Quality Control

Our (S)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid Methyl Ester is produced under strict quality management protocols to ensure batch-to-batch consistency and high chemical purity. We employ advanced analytical techniques, including chiral HPLC, to verify enantiomeric excess (ee) and identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.