Description

Tris(Trimethylsilyl)-D-Ribose is a high-purity, protected ribose derivative essential for advanced organic synthesis and pharmaceutical research. This compound serves as a critical building block for the controlled introduction of the D-ribose moiety into complex molecules, offering enhanced stability and solubility for demanding synthetic protocols. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for the synthesis of nucleoside analogs, antiviral agents, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of nucleoside-based antiviral and anticancer drugs.
• Carbohydrate Chemistry: Protected starting material for the stereoselective synthesis of complex oligosaccharides and glycoconjugates.
• Pro-drug Development: Used to create silyl-protected pro-drug forms of nucleoside analogs to improve bioavailability and metabolic stability.
• Chemical Biology Research: Tool compound for studying RNA metabolism and for incorporating modified ribose units into oligonucleotides.
• Fine Chemical Synthesis: Building block for creating chiral ligands, catalysts, and specialty fine chemicals requiring a defined ribose scaffold.

Basic Information

Product Name	Tris(Trimethylsilyl)-D-Ribose
CAS No.	79744-06-2
Molecular Formula	C14H34O5Si3
Molecular Weight	366.67 g/mol
Synonyms	1,2,3-Tri-O-trimethylsilyl-D-ribofuranose; D-Ribose, 1,2,3-tris-O-(trimethylsilyl)-; Tris-O-trimethylsilyl-D-ribofuranose; TMS-D-Ribose; Protected D-Ribose; Trimethylsilyl D-ribose derivative; 1,2,3-Tris(trimethylsilyloxy)ribofuranose
EINECS	Contact for details

Quality Control

Our Tris(Trimethylsilyl)-D-Ribose is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR for structural confirmation, and chiral analysis to ensure stereochemical integrity. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing purity, identity, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.