Description

(+-)-Pirbuterol Hydrochloride CAS NO 79645-08-2 is a racemic mixture of the β-2 adrenergic receptor agonist, pirbuterol, formulated as its hydrochloride salt. This compound is of significant interest in pharmaceutical research and development, particularly for its bronchodilatory properties. It serves as a key intermediate or active pharmaceutical ingredient (API) for researchers and manufacturers developing treatments for respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD).

Application

• Pharmaceutical Intermediate: Primary use as a building block in the synthesis of advanced respiratory therapeutics.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in API manufacturing.
• Pharmacological Research: Used in preclinical studies to investigate β-2 adrenergic receptor activity and mechanisms of bronchodilation.
• Formulation Development: Employed in R&D for creating inhalable dosage forms, including metered-dose inhalers (MDIs) and dry powder inhalers (DPIs).
• Impurity Profiling: Acts as a marker or impurity standard in the chromatographic analysis of related pharmaceutical compounds.

Basic Information

Product Name	(+-)-Pirbuterol Hydrochloride
CAS No.	79645-08-2
Molecular Formula	C12H21N3O3 • HCl
Molecular Weight	291.77 g/mol (free base: 255.31 g/mol)
Synonyms	Pirbuterol HCl; (±)-Pirbuterol Hydrochloride; 2-Hydroxy-5-[(1RS)-1-hydroxy-2-[[(1,1-dimethylethyl)amino]methyl]butyl]-1,3-benzenedimethanol hydrochloride; 3-Hydroxy-α-[[(1,1-dimethylethyl)amino]methyl]-6-(hydroxymethyl)-1,2-benzenedimethanol hydrochloride; Exirel (trade name related); CP-24314-1 (developmental code).
EINECS	Contact for details

Quality Control

Our (+-)-Pirbuterol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) detailing specifications such as assay, related substances, residual solvents, and microbiological quality, supporting compliance with cGMP and ICH guidelines for pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.