Description

5-Bromo-1-(Prop-2-Yn-1-Yl)-2,3-Dihydro-1H-Indole-2,3-Dione is a high-value synthetic intermediate characterized by its brominated indole-2,3-dione (isatin) core and a propargyl functional group. This unique molecular architecture makes it a versatile and critical building block for advanced organic synthesis, particularly in the development of novel pharmacologically active compounds. It is primarily sought after by research institutions and pharmaceutical companies engaged in medicinal chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex molecules for drug discovery, particularly in developing kinase inhibitors, anti-cancer agents, and central nervous system (CNS) active compounds.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and combinatorial chemistry libraries due to its reactive bromine and alkyne moieties, which allow for diverse chemical modifications.
• Agrochemical Synthesis: Employed in the research and development of new active ingredients for crop protection, leveraging the bioactivity of the isatin scaffold.
• Chemical Biology Probes: Utilized in the creation of molecular probes and tags, where the alkyne group enables click chemistry conjugation for labeling and tracking studies.
• Material Science Research: Acts as a monomer or functional unit in the synthesis of specialized polymers and organic electronic materials.

Basic Information

Product Name	5-Bromo-1-(Prop-2-Yn-1-Yl)-2,3-Dihydro-1H-Indole-2,3-Dione
CAS No.	79552-50-4
Molecular Formula	C11H6BrNO2
Molecular Weight	264.08 g/mol
Synonyms	5-Bromo-1-propargylisatin; 5-Bromo-1-(2-propynyl)-1H-indole-2,3-dione; 1-(Prop-2-yn-1-yl)-5-bromoindoline-2,3-dione; 5-Bromo-1-(prop-2-ynyl)isatin; 79552-50-4; 5-Bromo-1-(2-propynyl)isatin; 5-Bromo-1-propargyl-1H-indole-2,3-dione
EINECS	Contact for details

Quality Control

Our 5-Bromo-1-(Prop-2-Yn-1-Yl)-2,3-Dihydro-1H-Indole-2,3-Dione is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat sources and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥97.0% (Area %)
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.