Description

4-Hydroxy-2,2,6,6-Tetramethylpiperidine-1-15N-Oxyl is a stable nitroxide radical labeled with the 15N isotope, a key feature for advanced research applications. This compound is a critical spin label and probe in electron paramagnetic resonance (EPR) spectroscopy and dynamic nuclear polarization (DNP) for studying molecular structure, dynamics, and interactions. It is essential for researchers and manufacturers in pharmaceuticals, polymer science, and materials research who require precise, isotopically-labeled tools for mechanistic studies and quality control.

Application

• As a spin label in Electron Paramagnetic Resonance (EPR) spectroscopy for probing protein structure, membrane dynamics, and polymer morphology.
• A key polarizing agent in Dynamic Nuclear Polarization (DNP) for sensitivity enhancement in solid-state and solution NMR spectroscopy.
• Used as a radical trap and mechanistic probe in polymer chemistry to study polymerization kinetics and degradation mechanisms.
• Employed in the development of contrast agents and redox-active materials for medical imaging and biosensor applications.
• Acts as a catalyst or mediator in controlled oxidation reactions and organic synthesis methodologies.
• Utilized in fundamental research on radical chemistry, magnetic materials, and spin-labeled biomolecules.

Basic Information

Product Name	4-Hydroxy-2,2,6,6-Tetramethylpiperidine-1-15N-Oxyl
CAS No.	79494-16-9
Molecular Formula	C9H1815NO2
Molecular Weight	173.24 g/mol (for 15N isotopologue)
Synonyms	4-Hydroxy-TEMPO-15N; 4-Hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl-15N; 4-Hydroxy-15N-TEMPO; 4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl-15N; 4-Hydroxy-15N-labelled TEMPO; 1-Oxyl-2,2,6,6-tetramethyl-4-piperidinol-15N; 4-Hydroxy-TEMPO radical-15N; TEMPOL-15N
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-2,2,6,6-Tetramethylpiperidine-1-15N-Oxyl is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for chemical purity, EPR for radical content verification, and MS/NMR for isotopic enrichment confirmation, to ensure compliance with research-grade specifications. Certificates of Analysis (COA) detailing purity, isotopic enrichment, and all relevant analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep away from strong reducing agents and sources of heat.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (15N)	≥ 98 atom %
Radical Content (EPR)	≥ 97%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.