Description

(2S)-Dimethyl 8-Acetyl-6-Hydroxy-3,3A,8,8A-Tetrahydropyrrolo[2,3-B]Indole-1,2(2H)-Dicarboxylate is a high-purity, chiral synthetic intermediate of significant interest in advanced organic synthesis. Its complex, fused heterocyclic structure makes it a valuable building block for constructing sophisticated molecular architectures. This compound is primarily utilized by research institutions and pharmaceutical development teams working on novel active pharmaceutical ingredients (APIs) and complex natural product analogs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of potential drug candidates, particularly those with indole-based or polycyclic frameworks.
• Organic Synthesis Building Block: Used in complex multi-step syntheses to introduce a functionalized pyrroloindole core, enabling access to diverse chemical libraries for screening.
• Asymmetric Catalysis Research: Employed as a substrate or ligand precursor in the development and study of new asymmetric catalytic reactions due to its defined stereochemistry.
• Natural Product Synthesis: Acts as a synthetic analog or intermediate in the total synthesis of complex indole alkaloids and other natural products.
• Chemical Biology Probe Development: Utilized in the creation of specialized molecular probes to study biological pathways and protein interactions.
• Material Science Research: Investigated as a potential monomer or functional component for creating novel organic electronic materials or polymers with specific optical properties.

Basic Information

Item	Details
Product Name	(2S)-Dimethyl 8-Acetyl-6-Hydroxy-3,3A,8,8A-Tetrahydropyrrolo[2,3-B]Indole-1,2(2H)-Dicarboxylate
CAS No.	79465-86-4
Molecular Formula	C17H18N2O6
Molecular Weight	346.34 g/mol
Synonyms	(2S)-Dimethyl 8-acetyl-6-hydroxy-3,3a,8,8a-tetrahydro-1H-pyrrolo[2,3-b]indole-1,2-dicarboxylate; (S)-Dimethyl 8-acetyl-6-hydroxy-3,3a,8,8a-tetrahydro-1H-pyrrolo[2,3-b]indole-1,2-dicarboxylate; 8-Acetyl-6-hydroxy-3,3a,8,8a-tetrahydro-1H-pyrrolo[2,3-b]indole-1,2-dicarboxylic acid dimethyl ester, (3aR,8aS)-rel-; (3aR,8aS)-8-Acetyl-6-hydroxy-3,3a,8,8a-tetrahydro-1H-pyrrolo[2,3-b]indole-1,2-dicarboxylic acid dimethyl ester; Chiral Pyrroloindole Derivative; Dimethyl (2S)-8-acetyl-6-hydroxy-3,3a,8,8a-tetrahydropyrrolo[2,3-b]indole-1,2-dicarboxylate
EINECS	Contact for details

Quality Control

Our (2S)-Dimethyl 8-Acetyl-6-Hydroxy-3,3A,8,8A-Tetrahydropyrrolo[2,3-B]Indole-1,2(2H)-Dicarboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, verified by advanced analytical techniques including HPLC, NMR, and chiral analysis. We support cGMP compliance for advanced intermediates and can provide material for regulatory filing support upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.