Description

2-Trimethylsilylethyl 2-Bromoacetate is a versatile organosilicon-protected bromoacetic acid derivative, serving as a critical reagent in advanced organic synthesis. Its primary value lies in its dual functionality, where the silyl-protected alcohol provides stability and the bromoacetate moiety acts as a potent alkylating agent. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for the synthesis of complex molecules, peptide modifications, and the construction of novel chemical libraries.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of protease inhibitors and other targeted therapeutics.
• Peptide Chemistry: Used for the selective alkylation of amino acid side chains (e.g., cysteine residues) and the introduction of functional handles into peptide sequences.
• Agrochemical Synthesis: Intermediate in the production of herbicides, fungicides, and plant growth regulators requiring specific alkylation steps.
• Ligand and Catalyst Development: Employed to functionalize phosphines, amines, and other ligands to create novel catalytic systems for asymmetric synthesis.
• Polymer Modification: Acts as a functional monomer or cross-linking agent for introducing reactive bromoacetate groups into polymer backbones.
• Bioconjugation: Facilitates the attachment of small molecules, dyes, or drugs to proteins, antibodies, or other biomolecules for diagnostic and therapeutic applications.
• Material Science: Used in the surface functionalization of silica and other materials to create tailored interfaces with specific chemical reactivity.

Basic Information

Product Name	2-Trimethylsilylethyl 2-Bromoacetate
CAS No.	79414-13-4
Molecular Formula	C7H15BrO2Si
Molecular Weight	239.19 g/mol
Synonyms	2-Bromoacetic Acid 2-(Trimethylsilyl)ethyl Ester; (2-Trimethylsilyl)ethyl Bromoacetate; Bromoacetic Acid (2-Trimethylsilyl)ethyl Ester; 2-(Trimethylsilyl)ethyl α-Bromoacetate; TMS-Ethyl Bromoacetate; 2-Bromo-2-oxoethyl 2-(trimethylsilyl)ethyl ester; 79414-13-4; 2-(Trimethylsilyl)ethoxycarbonylmethyl Bromide (TMSECM-Br)
EINECS	Contact for details

Quality Control

Our 2-Trimethylsilylethyl 2-Bromoacetate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.