Description

7-Hydroxyaristolochic Acid A is a hydroxylated derivative of aristolochic acid, a class of compounds known for their distinct nitrophenanthrene carboxylic acid structure. This specific derivative is a critical reference standard and research chemical for analytical and pharmacological studies. It is primarily utilized by research institutions, pharmaceutical R&D departments, and analytical laboratories focusing on toxicology, natural product chemistry, and biomarker research.

Application

• Analytical Reference Standard: Used as a high-purity calibrant for the quantification of aristolochic acids and their metabolites in complex matrices via HPLC, LC-MS, or GC-MS.
• Pharmacological Research: Serves as a key compound in studies investigating the metabolism, bioactivation, and structure-activity relationships (SAR) of aristolochic acid nephropathy (AAN) and carcinogenicity.
• Toxicology Studies: Employed in in vitro and in vivo models to understand the specific toxicological profile and mechanisms of hydroxylated aristolochic acid derivatives.
• Biomarker Development: Acts as a synthetic standard for the development and validation of analytical methods aimed at detecting DNA adducts or urinary metabolites related to aristolochic acid exposure.
• Natural Product Chemistry: Used for comparative analysis in the isolation and characterization of aristolochic acid analogs from plant extracts and traditional herbal preparations.
• Quality Control for Herbal Products: Utilized by quality control laboratories to screen for and quantify the presence of specific, potentially harmful aristolochic acid derivatives in botanical ingredients and finished products to ensure consumer safety.

Basic Information

Product Name	7-Hydroxyaristolochic Acid A
CAS No.	79185-75-4
Molecular Formula	C17H11NO7
Molecular Weight	341.27 g/mol
Synonyms	7-Hydroxyaristolochic Acid A; 8-Methoxy-3,4-methylenedioxy-10-nitro-1-phenanthrenecarboxylic Acid, 7-Hydroxy derivative; Aristolochic Acid A 7-Hydroxy derivative; 7-Hydroxy-8-methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1-carboxylic Acid; 7-OH-AA-I; 7-OH-AAIA; 7-Hydroxy-AA-I; 7-Hydroxyaristolochic acid I
EINECS	Contact for details

Quality Control

Our 7-Hydroxyaristolochic Acid A is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant industry standards for reference materials to support your analytical and research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95.0%
Related Substances (HPLC)	Total impurities ≤5.0%
Loss on Drying	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.