Description

3-(2,2,2-Trifluoro-Acetylamino)-Thiophene-2-Carboxylicacidmethylester is a high-value trifluoromethylated heterocyclic building block, specifically a thiophene derivative, essential for introducing fluorine motifs into complex molecular architectures. Its core value lies in enabling the synthesis of novel compounds with enhanced metabolic stability, lipophilicity, and bioavailability, which are critical parameters in modern drug discovery. This advanced intermediate is primarily needed by pharmaceutical R&D departments and fine chemical manufacturers focused on developing new active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the trifluoromethyl group can improve compound activity, photostability, and environmental persistence.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, or organic electronic materials that benefit from fluorine incorporation for specific electronic or surface properties.
• Fluorine Chemistry & Library Synthesis: An important building block for constructing diverse compound libraries in high-throughput screening and for exploring structure-activity relationships (SAR) in fluorine chemistry.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the life sciences industry.

Basic Information

Product Name	3-(2,2,2-Trifluoro-Acetylamino)-Thiophene-2-Carboxylicacidmethylester
CAS No.	79128-68-0
Molecular Formula	C8H6F3NO3S
Molecular Weight	253.20 g/mol
Synonyms	Methyl 3-[(2,2,2-trifluoroacetyl)amino]thiophene-2-carboxylate; 3-[(Trifluoroacetyl)amino]-2-thiophenecarboxylic acid methyl ester; 2-Thiophenecarboxylic acid, 3-[(2,2,2-trifluoroacetyl)amino]-, methyl ester; Methyl 3-(trifluoroacetamido)thiophene-2-carboxylate; 3-(Trifluoroacetamido)thiophene-2-carboxylic acid methyl ester; 79128-68-0; 3-TFA-Amino-thiophene-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 3-(2,2,2-Trifluoro-Acetylamino)-Thiophene-2-Carboxylicacidmethylester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.