Description

D-Proline, 3-Mercoptan-, (3S)-Rel- (9Ci) is a specialized non-proteinogenic amino acid derivative featuring a unique thiol group on the proline ring. This compound is a valuable chiral building block and ligand in asymmetric synthesis and pharmaceutical research. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, peptide mimetics, and catalysts. The distinct stereochemistry and functional group make it a critical intermediate for creating complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other targeted therapies.
• Peptidomimetics & Drug Design: Used to construct constrained peptide analogs and scaffolds that mimic natural peptide structures, enhancing metabolic stability and bioavailability.
• Asymmetric Catalysis: Acts as a ligand or precursor for chiral catalysts in enantioselective synthesis, crucial for producing optically pure compounds.
• Biochemical Research: Employed in studying enzyme mechanisms, protein-protein interactions, and as a tool compound in chemical biology.
• Material Science: Potential applications in creating functionalized surfaces or polymers where specific chirality and thiol reactivity are required.

Basic Information

Product Name	D-Proline, 3-Mercapto-, (3S)-Rel- (9Ci)
CAS No.	79068-22-7
Molecular Formula	C5H9NO2S
Molecular Weight	147.20 g/mol
Synonyms	(3S)-3-Mercapto-D-proline; (3S)-3-Thiol-D-proline; D-3-Mercaptoproline; (R)-3-Mercaptoproline (referring to the α-carbon configuration); rel-(3S)-3-Mercapto-D-proline; 3-Thio-D-proline; 3-Sulfanyl-D-proline; 79068-22-7 (CAS)
EINECS	Contact for details

Quality Control

Our D-Proline, 3-Mercapto-, (3S)-Rel- (9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including chiral purity verification, assay, and impurity profiling to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specific test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and easily oxidized nature. Allow the container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.