Description

D-Proline, 3-Mercato-, (3R)-Rel- (9Ci) is a non-proteinogenic amino acid derivative featuring a proline backbone with a thiol (mercapto) functional group at the 3-position. This compound matters as a versatile chiral building block and ligand, prized for its ability to introduce sulfur-based reactivity and stereochemical control into complex molecular architectures. It is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for applications in asymmetric synthesis, catalysis, and the development of novel bioactive compounds. The product is supplied under high-purity conditions to ensure optimal performance in sensitive chemical processes.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly protease inhibitors and other enzyme-targeted therapies.
• Catalyst Ligand: Used in the development of asymmetric catalysts for enantioselective transformations in fine chemical synthesis.
• Peptidomimetic Research: Serves as a constrained scaffold in the design and synthesis of peptidomimetics to modulate biological activity and stability.
• Agrochemical Synthesis: Employed as a building block for creating advanced, chiral active ingredients with specific modes of action.
• Bioconjugation Chemistry: The thiol group enables site-specific modification of proteins, peptides, and other biomolecules.
• Material Science: Investigated for use in creating functionalized surfaces and polymers with tailored properties.

Basic Information

Product Name	D-Proline, 3-Mercapto-, (3R)-Rel- (9Ci)
CAS No.	79068-20-5
Molecular Formula	C5H9NO2S
Molecular Weight	147.20 g/mol
Synonyms	(3R)-3-Mercapto-D-proline; D-3-Mercaptoproline; (R)-3-Mercapto-D-proline; rel-(3R)-3-Mercapto-D-proline; 3-Thiol-D-proline; 3-Sulfanyl-D-proline; (R)-3-Thiolproline; 79068-20-5
EINECS	Contact for details

Quality Control

Our D-Proline, 3-Mercapto-, (3R)-Rel- (9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing identity, purity (typically ≥95% by HPLC), and specific tests are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation of the thiol group. The material is moisture-sensitive; keep the container tightly sealed in a cool, dry, and well-ventilated place. For long-term storage, consider freezing at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.