Description

5Alpha-Androstan-3Alpha,17Beta-Diol-16,16,17-D3 is a high-purity, deuterium-labeled steroid reference standard, essential for precise analytical quantification and metabolic research. This compound is critical for ensuring accuracy and reliability in mass spectrometry-based assays, where it serves as an internal standard to correct for variations in sample preparation and instrument performance. It is primarily required by pharmaceutical R&D laboratories, clinical research organizations, and analytical testing facilities engaged in steroid hormone analysis, drug metabolism studies, and anti-doping control.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the accurate quantification of endogenous androgenic steroids and their metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Facilitates studies on the absorption, distribution, metabolism, and excretion (ADME) of steroid-based pharmaceuticals.
• Clinical Diagnostics: Supports the development and validation of high-sensitivity assays for hormonal disorders, such as congenital adrenal hyperplasia or androgen excess.
• Anti-Doping Analysis: A key reference material in sports drug testing to detect the abuse of endogenous anabolic androgenic steroids.
• Biochemical Research: Employed in mechanistic studies of steroid hormone biosynthesis, conversion, and receptor interaction pathways.
• Pharmaceutical Quality Control: Used in the analysis and stability testing of steroid-containing drug products to ensure potency and purity.

Basic Information

Product Name	5Alpha-Androstan-3Alpha,17Beta-Diol-16,16,17-D3
CAS No.	79037-33-5
Molecular Formula	C19H29D3O2
Molecular Weight	293.48 g/mol
Synonyms	5α-Androstane-3α,17β-diol-16,16,17-d3; 5α-Androstan-3α,17β-diol-d3; 3α,17β-Androstanediol-d3; 5α-Dihydrotestosterone metabolite-d3; 5α-Diol-d3; Androstanediol-d3; 16,16,17-D3-5α-Androstane-3α,17β-diol
EINECS	Contact for details

Quality Control

Our deuterated reference standards are produced under strict quality management to ensure the highest isotopic purity and chemical integrity, which is non-negotiable for quantitative analysis. Each batch is characterized using advanced techniques including NMR and high-resolution mass spectrometry to confirm deuteration level and positional specificity. A comprehensive Certificate of Analysis (COA) is provided, detailing assay purity, isotopic enrichment, and analytical results. We support compliance with ISO 17034 and GMP guidelines for reference material producers.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, storage at 2-8°C is recommended.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Chemical Purity (NMR)	≥ 95%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.