Description

Cortisol-1,2-D2 is a deuterium-labeled analog of the endogenous glucocorticoid hormone cortisol (hydrocortisone). This stable isotope-labeled compound is an essential tool for quantitative mass spectrometry analysis, enabling precise measurement of cortisol levels in complex biological matrices. It is primarily utilized by research institutions, pharmaceutical companies, and clinical diagnostic laboratories engaged in endocrinology research, drug metabolism studies, and the development of high-sensitivity LC-MS/MS assays.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard for the accurate quantification of endogenous cortisol in biological samples (e.g., serum, plasma, urine, saliva).
• Endocrinology and Clinical Research: Used in studies investigating adrenal function, stress response, Cushing's syndrome, and Addison's disease.
• Pharmacokinetics & Drug Metabolism Studies (DMPK): Employed as a tracer to study the metabolism, bioavailability, and clearance of corticosteroid drugs.
• Diagnostic Assay Development: A key component in the development and validation of robust clinical diagnostic tests for hormone level assessment.
• Biomarker Discovery and Validation: Facilitates precise measurement in proteomic and metabolomic research aiming to discover hormonal biomarkers.
• Quality Control in Pharmaceutical Analysis: Used in GLP/GMP environments to ensure accuracy and precision in the analysis of corticosteroid-based pharmaceuticals.

Basic Information

Product Name	Cortisol-1,2-D2
CAS No.	79037-25-5
Molecular Formula	C₂₁H₂₈D₂O₅
Molecular Weight	364.47 g/mol
Synonyms	11β,17α,21-Trihydroxypregn-4-ene-3,20-dione-1,2-d2; [1,2-D2]-Cortisol; Deuterated Cortisol; Hydrocortisone-1,2-d2; 11β,17,21-Trihydroxy-4-pregnene-3,20-dione-1,2-d2; [1,2-D2]-11β,17α,21-Trihydroxypregn-4-ene-3,20-dione; Stable Isotope-Labeled Cortisol
EINECS	Contact for details

Quality Control

Our Cortisol-1,2-D2 is produced and handled under strict quality protocols. Each batch undergoes rigorous analytical testing, including HPLC for chemical purity and isotopic enrichment analysis (e.g., NMR, MS) to confirm deuterium incorporation and position. We provide comprehensive Certificates of Analysis (COA) detailing purity, isotopic purity, and analytical results. Our quality system supports compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to expected mass spectrum
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D (by MS or NMR)
Chemical Purity	≥ 95% (by NMR)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.