Description

Tertiary-Butyloxycarbonyl-L-Iodotyrosine-n-Hydroxysuccinimide Ester is a high-purity, activated ester derivative of iodotyrosine, specifically designed for peptide synthesis and bioconjugation. This compound matters as a critical building block for introducing the unique iodine-labeled tyrosine residue into peptides and proteins under mild conditions, enabling advanced research in radiopharmaceuticals, molecular imaging, and proteomics. It is essential for pharmaceutical R&D scientists, radiochemists, and biochemists working on targeted drug delivery systems, diagnostic agent development, and site-specific protein modification.

Application

• Peptide Synthesis: Key reagent for the solid-phase or solution-phase incorporation of iodine-labeled tyrosine, facilitating the creation of novel peptide sequences for biological evaluation.
• Radiopharmaceutical Precursor: Serves as a crucial intermediate in the synthesis of iodine-123 or iodine-125 labeled compounds used in Single Photon Emission Computed Tomography (SPECT) imaging and radiotherapy.
• Bioconjugation & Protein Labeling: Used to site-specifically label antibodies, enzymes, and other proteins with iodine tags for tracking, detection, and functional studies.
• Proteomics Research: Enables the study of protein-protein interactions, post-translational modifications, and cellular localization through iodine-based tagging strategies.
• Diagnostic Agent Development: A foundational component in developing targeted diagnostic probes for cancer, neurological disorders, and cardiovascular diseases.
• Chemical Biology Tool: Utilized in activity-based protein profiling (ABPP) and other chemical proteomics approaches to explore enzyme function and drug targets.

Basic Information

Product Name	Tertiary-Butyloxycarbonyl-L-Iodotyrosine-n-Hydroxysuccinimide Ester
CAS No.	79028-57-2
Molecular Formula	C18H21IN2O7
Molecular Weight	504.28 g/mol
Synonyms	Boc-L-Iodotyrosine-OSu; Boc-Tyr(I)-OSu; N-α-Boc-O-(3-iodo)-L-tyrosine N-hydroxysuccinimide ester; Boc-L-Tyr(3-I)-OSu; t-Butyloxycarbonyl-L-iodotyrosine N-succinimidyl ester; Boc-Tyr(3-I)-OSu; (2,5-Dioxopyrrolidin-1-yl) (2S)-3-(4-hydroxy-3-iodophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate; Boc-L-3-Iodotyrosine N-hydroxysuccinimide ester
EINECS	Contact for details

Quality Control

Our Tertiary-Butyloxycarbonyl-L-Iodotyrosine-n-Hydroxysuccinimide Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.