Description

S(-)-8-Hydroxy-DPAT Hydrobromide is a potent and selective partial agonist for the 5-HT1A serotonin receptor subtype, widely utilized as a critical reference standard and research tool in neuropharmacology. Its high selectivity makes it indispensable for studying receptor function, signal transduction pathways, and the development of novel therapeutics targeting the central nervous system. This compound is essential for pharmaceutical R&D laboratories, academic research institutions, and contract research organizations (CROs) focused on neuroscience, psychiatry, and drug discovery.

Application

• Neuroscience Research: A key pharmacological tool for in vitro and in vivo studies of 5-HT1A receptor function, localization, and density.
• Drug Discovery & Development: Used as a reference compound for high-throughput screening (HTS) and lead optimization in CNS drug discovery programs.
• Behavioral Pharmacology: Employed in animal models to investigate anxiety, depression, and other neuropsychiatric disorders linked to serotonergic systems.
• Biochemical Assays: Serves as a standard for receptor binding assays (e.g., competitive displacement studies) and functional assays (e.g., cAMP inhibition).
• Academic & Clinical Research: Fundamental for university labs and clinical research facilities exploring serotonin's role in brain physiology and pathology.
• Analytical Reference Standard: Used in HPLC, LC-MS, and other analytical methods for method development, validation, and quality control of related compounds.

Basic Information

Product Name	S(-)-8-Hydroxy-DPAT Hydrobromide
CAS No.	78950-78-4
Molecular Formula	C16H25N2O2 • HBr
Molecular Weight	357.30 g/mol
Synonyms	(S)-8-Hydroxy-DPAT HBr; (S)-8-OH-DPAT Hydrobromide; (S)-8-Hydroxy-2-(di-n-propylamino)tetralin Hydrobromide; S(-)-8-OH-DPAT HBr; 5-HT1A Partial Agonist; (S)-(-)-8-Hydroxy-DPAT HBr; (2S)-8-Hydroxy-2-(dipropylamino)-1,2,3,4-tetrahydronaphthalene Hydrobromide
EINECS	Contact for details

Quality Control

Our S(-)-8-Hydroxy-DPAT Hydrobromide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management standards, and our analytical methods are validated to meet the rigorous requirements of pharmaceutical reference standard production.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.