Description

1-o-Hexadecyl-2-o-Methyl-Sn-Glyceryl-3-Phosphorylcholine is a high-purity synthetic phospholipid derivative, specifically an ether-linked phosphatidylcholine analogue. This compound is a critical building block for advanced lipid-based formulations, offering superior chemical stability compared to its ester-linked counterparts. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for developing next-generation drug delivery systems, such as liposomes and lipid nanoparticles (LNPs), as well as in biochemical research as a membrane model component.

Application

• Lipid Nanoparticle (LNP) Formulation: A key structural lipid for constructing stable, non-viral delivery vehicles for mRNA, siRNA, and other nucleic acid therapeutics.
• Advanced Liposome Development: Used to create liposomal bilayers with enhanced oxidative stability and tailored membrane fluidity for targeted drug delivery.
• Biomimetic Membrane Research: Serves as a stable, synthetic phospholipid component in model membrane systems for biophysical and biochemical studies.
• Excipient for Injectable Formulations: Potential functional excipient in parenteral formulations requiring highly stable lipid components.
• Reference Standard: Employed as a high-purity analytical standard in pharmaceutical quality control and lipidomics research.

Basic Information

Item	Detail
Product Name	1-o-Hexadecyl-2-o-Methyl-Sn-Glyceryl-3-Phosphorylcholine
CAS No.	78858-44-3
Molecular Formula	C25H54NO6P
Molecular Weight	495.68 g/mol
Synonyms	1-Hexadecyl-2-methyl-rac-glycero-3-phosphocholine; 1-O-Hexadecyl-2-O-methyl-sn-glycero-3-phosphocholine; C16:0 Methyl Ether PC; Ether PC (16:0/Me); 1-Palmitoyl-2-methyl-phosphatidylcholine (ether-linked); rac-1-Hexadecyl-2-methylglycero-3-phosphocholine; Lyso-PAF C-16 analogue; Phospholipid 78858-44-3
EINECS	Contact for details

Quality Control

Our 1-o-Hexadecyl-2-o-Methyl-Sn-Glyceryl-3-Phosphorylcholine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical characterization using techniques including NMR, HPLC, and mass spectrometry to confirm identity, isomeric purity, and chemical purity. We provide full traceability and Certificates of Analysis (COA) are available for every lot, detailing all critical quality attributes. Production can adhere to cGMP guidelines for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (NMR)	Complies with structure
Purity (HPLC)	≥ 95.0%
Isomeric Purity (sn-1 isomer)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.