Description

L-Proline,4-Merco-,Hydrochloride(1:1) is a high-purity, non-proteinogenic amino acid derivative, specifically the hydrochloride salt of 4-mercapto-L-proline. This compound is a critical chiral building block and intermediate in advanced pharmaceutical synthesis and biochemical research. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors requiring a high-quality, reliable source of this specialized thiol-containing proline analog for developing novel therapeutics and conducting proteomics studies.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly protease inhibitors and other biologically active molecules.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce a thiol-functionalized proline residue, enabling disulfide bridge formation or site-specific conjugation.
• Biochemical Research: Serves as a precursor or standard in enzymatic studies, metabolic pathway analysis, and as a tool compound in proteomics.
• Ligand for Metal Complexation: The thiol and carboxylate groups make it a potential chelating agent for creating metal complexes in catalysis or imaging agents.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	L-Proline,4-Mercapto-,Hydrochloride(1:1)
CAS No.	78854-27-0
Molecular Formula	C5H9NO2S • HCl
Molecular Weight	199.66 g/mol
Synonyms	(2S)-4-Sulfanylproline hydrochloride; 4-Mercapto-L-proline hydrochloride; 4-Thiaproline hydrochloride; (2S)-4-Mercaptopyrrolidine-2-carboxylic acid hydrochloride; L-4-Mercaptoproline HCl; 4-Mercaptoproline monohydrochloride; (S)-4-Mercaptoproline hydrochloride; 4-SH-Pro-OH • HCl
EINECS	Contact for details

Quality Control

Our L-Proline,4-Mercapto-,Hydrochloride(1:1) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the stringent requirements for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.