Description

Amicoumacin A is a potent antibiotic and anti-inflammatory compound belonging to the isocoumarin class of natural products. This high-purity chemical is valued for its significant biological activity, making it a critical reference standard and research material. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in antimicrobial and anti-inflammatory drug discovery programs.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel antibiotic and anti-inflammatory agents.
• Antimicrobial Studies: Used in microbiological research to study mechanisms of action against a broad spectrum of bacteria, including drug-resistant strains.
• Biochemical Pathway Analysis: Employed as a molecular probe to investigate bacterial protein synthesis inhibition and related cellular pathways.
• Natural Product Chemistry: Acts as a pure compound for structural-activity relationship (SAR) studies to synthesize more potent or stable analogs.
• Academic & Institutional Research: Utilized in university and government laboratories for fundamental research in microbiology, pharmacology, and medicinal chemistry.
• Biotech Product Development: Incorporated into screening libraries for high-throughput assays to identify new therapeutic leads.

Basic Information

Product Name	Amicoumacin A
CAS No.	78683-77-9
Molecular Formula	C₃₆H₄₅NO₁₄
Molecular Weight	703.74 g/mol
Synonyms	AI-77; AI 77; AI-77-B; Amicoumacin; Amicoumacin A; Antibiotic AI 77-B; Antibiotic AI-77; Antibiotic AI-77-B; (3S)-3-[[(2S)-2-[[(2S,3R)-3-[[(2S)-5-Amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]pentanoyl]amino]-2-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-8-hydroxy-3,4-dihydro-1H-isochromene-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our Amicoumacin A is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and microbiological assays for potency verification. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to maintain stability and potency. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Potency (Microbiological Assay)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.