Description

3-Hydroxy-3-[2-Oxo-2-(Thiophen-2-Yl)Ethyl]-1,3-Dihydro-2H-Indol-2-One is a high-purity, synthetically valuable heterocyclic compound featuring a unique molecular scaffold that combines indolinone and thiophene moieties. This structure makes it a critical advanced pharmaceutical intermediate and a versatile building block for medicinal chemistry research and fine chemical synthesis. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active molecules.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Medicinal Chemistry Research: Used as a privileged scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Agrochemical Synthesis: Acts as a building block for developing new active ingredients with potential herbicidal or insecticidal properties.
• Fine Chemical Production: Employed in the custom synthesis of complex, high-value specialty chemicals for various industrial applications.
• Academic Research: Utilized in universities and research institutes for studying heterocyclic chemistry, reaction mechanisms, and new synthetic methodologies.

Basic Information

Product Name	3-Hydroxy-3-[2-Oxo-2-(Thiophen-2-Yl)Ethyl]-1,3-Dihydro-2H-Indol-2-One
CAS No.	78660-85-2
Molecular Formula	C₁₄H₁₁NO₃S
Molecular Weight	273.31 g/mol
Synonyms	3-Hydroxy-3-(2-oxo-2-thiophen-2-ylethyl)indolin-2-one; 2-Oxo-2-(thiophen-2-yl)-1-(2-oxoindolin-3-ylidene)ethan-1-ol; 3-Hydroxy-3-(2-thienylcarbonylmethyl)oxindole; 3-(2-Oxo-2-thiophen-2-ylethyl)-3-hydroxyindolin-2-one; Isatin, 3-hydroxy-3-[2-oxo-2-(2-thienyl)ethyl]-; 78660-85-2; 3-Hydroxy-3-(2-thiophen-2-yl-2-oxoethyl)indolin-2-one
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for this advanced intermediate. Production follows current Good Manufacturing Practice (cGMP) principles where applicable, and each batch is analyzed using advanced techniques like HPLC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.