Description

5-Iodo-1H-Benzimidazole is a halogenated benzimidazole derivative, a versatile heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its iodine substituent, which serves as a reactive handle for further functionalization via cross-coupling reactions, making it a critical intermediate for creating complex molecular architectures. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting kinases, viral enzymes, and GPCRs.
• Agrochemical Research: Used in the development of new fungicides, herbicides, and plant growth regulators that leverage the benzimidazole scaffold.
• Ligand Synthesis: Serves as a starting material for creating specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science: Employed in the research and development of organic semiconductors, OLED materials, and photoactive compounds.
• Cross-Coupling Reactions: The iodine atom is ideal for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings to form carbon-carbon and carbon-heteroatom bonds.
• Chemical Biology Probes: Useful for synthesizing tagged molecules and probes for studying biological processes and target engagement.

Basic Information

Product Name	5-Iodo-1H-Benzimidazole
CAS No.	78597-27-0
Molecular Formula	C7H5IN2
Molecular Weight	244.03 g/mol
Synonyms	5-Iodo-1H-benzo[d]imidazole; 1H-Benzimidazole, 5-iodo-; 5-Iodobenzimidazole; Benzimidazole, 5-iodo-; 78597-27-0; AI3-52511; SCHEMBL118275; ZINC000004043773; BDBM50388885; AKOS005209209; FT-0654847; NS00012583; A812417
EINECS	Contact for details

Quality Control

Our 5-Iodo-1H-Benzimidazole is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure compliance with research and development standards. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.