Description

4-Ethynylisoquinoline is a specialized heterocyclic building block featuring an isoquinoline core functionalized with a terminal alkyne group. This unique molecular architecture makes it a high-value intermediate for constructing complex molecules through cross-coupling and cycloaddition reactions. It is primarily utilized by pharmaceutical researchers and agrochemical developers in the synthesis of novel active compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in kinase inhibitor and anticancer agent research.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and plant growth regulators.
• Material Science Research: Serves as a monomer or precursor for creating advanced organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology: Employed in click chemistry applications for bioconjugation and probe development due to its reactive ethynyl group.
• Catalyst Ligand Synthesis: Precursor for creating novel nitrogen-containing ligands used in homogeneous catalysis.
• Academic & R&D: Fundamental research reagent in organic and medicinal chemistry laboratories for method development and library synthesis.

Basic Information

Product Name	4-Ethynylisoquinoline
CAS No.	78593-42-7
Molecular Formula	C11H7N
Molecular Weight	153.18 g/mol
Synonyms	Isoquinoline, 4-ethynyl-; 4-Ethynyl-isoquinoline; 4-Ethynylisoquinoline; 4-Isoquinolinylacetylene; 4-(Ethynyl)isoquinoline; 1-Aza-4-ethynylnaphthalene
EINECS	Contact for details

Quality Control

Our 4-Ethynylisoquinoline is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to reliable supply and transparent documentation supports your R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). The compound may be sensitive to prolonged exposure to air and moisture; it is recommended to handle under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.