Description

4-Fluoro-Bicyclo[2.2.2]Octan-1-Amine is a structurally unique, fluorinated bicyclic amine building block. This compound matters for its role as a key intermediate in advanced organic synthesis, particularly in medicinal chemistry where its rigid, three-dimensional scaffold and fluorine atom are leveraged to modulate the physicochemical and biological properties of target molecules. It is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical intermediate for the synthesis of novel drug candidates, especially in central nervous system (CNS) and metabolic disease research.
• Key building block in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Precursor for the development of advanced agrochemicals, including herbicides and fungicides with new modes of action.
• Starting material for chiral ligands and catalysts used in asymmetric synthesis.
• Monomer or functional additive in the development of specialty polymers and advanced materials.
• Intermediate in the synthesis of fluorinated compounds for positron emission tomography (PET) imaging agents.

Basic Information

Product Name	4-Fluoro-Bicyclo[2.2.2]Octan-1-Amine
CAS No.	78385-91-8
Molecular Formula	C8H14FN
Molecular Weight	143.20 g/mol
Synonyms	1-Amino-4-fluorobicyclo[2.2.2]octane; 4-Fluorobicyclo[2.2.2]octan-1-amine; 4-Fluoro-1-aminobicyclo[2.2.2]octane; 1-Bicyclo[2.2.2]octanyl-4-fluoroamine; 4-Fluoro-BCO-1-amine; 4-F-BCO-NH2; 4-Fluoro-1-azabicyclo[2.2.2]octane (related structure); exo-4-Fluorobicyclo[2.2.2]octan-1-amine
EINECS	Contact for details

Quality Control

Our 4-Fluoro-Bicyclo[2.2.2]Octan-1-Amine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We can support development projects requiring compliance with cGMP or other regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.