Description

Aspartic Acid, D-[2,3-3H] CAS NO 78333-14-9 is a high-specific-activity, tritium-labeled derivative of D-aspartic acid, a key non-proteinogenic amino acid. This radiolabeled compound is essential for advanced research requiring precise metabolic and biochemical pathway tracing. It is primarily utilized by scientists and quality control professionals in the pharmaceutical, biotechnology, and life science research sectors for applications such as receptor binding studies, amino acid transport assays, and metabolic research.

Application

• Biochemical Research & Tracer Studies: Used as a radioactive tracer to investigate the metabolism, transport, and biochemical pathways of D-aspartic acid in biological systems.
• Neuropharmacology: Critical for receptor binding assays and studies of NMDA (N-methyl-D-aspartate) receptor function and neurotransmission.
• Metabolic Pathway Analysis: Enables detailed tracking of amino acid incorporation and turnover in cell culture and in vivo models.
• Pharmaceutical Development: Supports ADME (Absorption, Distribution, Metabolism, and Excretion) studies for drug candidates targeting neurological pathways.
• Diagnostic Agent Research: Serves as a precursor in the research and development of potential PET (Positron Emission Tomography) imaging agents.
• Enzymology Studies: Used to study enzyme kinetics and mechanisms involving D-aspartate, such as those of D-aspartate oxidase.

Basic Information

Product Name	Aspartic Acid, D-[2,3-3H]
CAS No.	78333-14-9
Molecular Formula	C4H7NO4 (³H labeled)
Molecular Weight	~135.11 g/mol (varies with specific activity)
Synonyms	(2R)-2-Aminobutanedioic acid-2,3-³H; D-Aspartic-2,3-³H acid; Tritiated D-Aspartic Acid; D-AA-2,3-³H; (R)-Aminobutanedioic acid-2,3-³H; D-Asp-2,3-³H; ³H-D-Aspartic Acid; D-[2,3-³H]Asp
EINECS	Contact for details

Quality Control

Every batch of Aspartic Acid, D-[2,3-3H] is manufactured and analyzed under strict quality systems to ensure high radiochemical purity and specific activity. Quality is verified via advanced analytical techniques including HPLC with radiometric detection. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specific activity, radiochemical purity, chemical purity, and solvent composition. Our production adheres to cGMP guidelines suitable for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C. This product is hygroscopic (moisture-sensitive). For long-term storage, solutions are recommended to be kept in sealed vials under inert atmosphere. Handle and dispose of in accordance with all applicable radiation safety regulations and guidelines.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Specific Activity	10-40 Ci/mmol (Contact for exact value)
Radiochemical Purity (HPLC)	≥ 95%
Chemical Purity (HPLC)	≥ 98%
Concentration	1 mCi/mL in aqueous ethanol or specified solvent
Identification (IR/NMR)	Conforms to structure
Solvent Composition	Ethanol:Water (7:3) or as specified

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.