Description

(S)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid Methyl Ester Hydrochloride is a high-purity chiral building block essential for advanced pharmaceutical synthesis. This compound serves as a critical intermediate in the development of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular therapeutics. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in enantioselective synthesis and process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, including potential candidates for neurological disorders.
• Asymmetric Synthesis: Used in the construction of enantiomerically pure tetrahydroisoquinoline scaffolds, which are common structural motifs in medicinal chemistry.
• Process Research & Development (R&D): Employed in route scouting and optimization for the scalable production of target APIs.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development and quality control in pharmaceutical manufacturing.
• Academic Research: Utilized in university and institutional labs for studying synthetic methodologies and structure-activity relationships (SAR).
• Peptidomimetics: Acts as a constrained amino acid derivative in the design and synthesis of peptide analogs with enhanced metabolic stability.

Basic Information

Product Name	(S)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid Methyl Ester Hydrochloride
CAS No.	78183-55-8
Molecular Formula	C12H16ClNO2
Molecular Weight	241.71 g/mol
Synonyms	(S)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid methyl ester hydrochloride; (S)-Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride; (S)-Tic-OMe·HCl; (S)-3-Carbomethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride; L-TIQ-3-COOMe·HCl; Methyl (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate HCl; (3S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid methyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid Methyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.