Description

(S)-Tetrahydro-3-Isoquinolinecarboxylicacid is a chiral, non-proteinogenic amino acid derivative of significant synthetic utility. This compound serves as a crucial pharmaceutical intermediate and a versatile chiral building block for the construction of complex organic molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the development of active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the synthesis of drug candidates targeting neurological and cardiovascular disorders.
• Peptidomimetics Research: Used to incorporate constrained, rigid amino acid analogs into peptide chains to study structure-activity relationships and improve metabolic stability.
• Asymmetric Synthesis: Acts as a chiral auxiliary or precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Medicinal Chemistry: Building block for creating focused libraries of small molecules for high-throughput screening and lead optimization.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes to study enzyme function and biological pathways.
• Fine Chemical Production: Intermediate in the multi-step synthesis of specialty chemicals, agrochemicals, and advanced materials.

Basic Information

Product Name	(S)-Tetrahydro-3-Isoquinolinecarboxylicacid
CAS No.	77947-97-3
Molecular Formula	C10H11NO2
Molecular Weight	177.20 g/mol
Synonyms	(S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid; (3S)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic Acid; (S)-Tic-OH; (S)-Tic; L-Tic; (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylate; (3S)-3-Carboxy-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

We maintain a strict quality management system to ensure batch-to-batch consistency and high purity. Our products undergo rigorous quality testing, including chiral purity analysis, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles are available upon request. We can supply material compliant with cGMP standards for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.