Description

n-Acetyl-(4R)-Isopropyl 2-Oxazolidinone is a high-purity, chiral auxiliary and building block of significant importance in asymmetric synthesis. Its value lies in enabling the stereoselective construction of complex molecules, a critical process for developing pharmaceuticals and advanced materials. This compound is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for the production of enantiomerically pure active ingredients and intermediates.

Application

• Chiral Auxiliary in Asymmetric Synthesis: Used to control stereochemistry in key bond-forming reactions such as aldol, alkylation, and Diels-Alder reactions.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular drugs.
• Agrochemical Synthesis: Employed in the research and development of chiral herbicides, fungicides, and pesticides where specific stereochemistry is required for optimal activity.
• Catalyst and Ligand Precursor: Acts as a starting material for the synthesis of novel chiral catalysts and ligands used in homogeneous catalysis.
• Academic and Process Chemistry Research: A valuable tool for developing new synthetic methodologies and scaling up stereoselective processes in laboratory and pilot plant settings.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, flavors, and fragrances that require high enantiomeric purity.

Basic Information

Product Name	n-Acetyl-(4R)-Isopropyl 2-Oxazolidinone
CAS No.	77887-48-0
Molecular Formula	C8H13NO3
Molecular Weight	171.19 g/mol
Synonyms	(4R)-4-Isopropyl-3-acetyl-2-oxazolidinone; (R)-4-Isopropyl-3-acetyloxazolidin-2-one; (R)-3-Acetyl-4-isopropyloxazolidin-2-one; Evans Chiral Auxiliary Derivative; N-Acetyl-(R)-4-isopropyl-2-oxazolidinone; Acetyl-(R)-4-isopropyl-2-oxazolidinone; (R)-N-Acetyl-4-isopropyl-2-oxazolidinone
EINECS	Contact for details

Quality Control

Our n-Acetyl-(4R)-Isopropyl 2-Oxazolidinone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for asymmetric synthesis. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.