Description

3α,6β-Bis[(Trimethylsilyl)Oxy]-5α-Cholestane CAS NO 77828-33-2 is a high-purity, silylated derivative of cholestane, a key steroid backbone. This compound serves as a critical advanced intermediate and analytical reference standard in sophisticated organic synthesis and pharmaceutical research. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers working on steroid-based therapeutics, metabolic studies, and analytical method development.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex steroid-based active pharmaceutical ingredients (APIs) and novel drug candidates.
• Analytical Reference Standard: Used for method development, validation, and quality control in HPLC, GC-MS, and LC-MS analysis of steroid compounds and their metabolites.
• Metabolic Pathway Research: Employed as a probe or labeled precursor in studies investigating cholesterol metabolism and steroid hormone biosynthesis.
• Chemical Derivatization Agent: Utilized in analytical chemistry to enhance the volatility, stability, or detectability of related steroid compounds for chromatographic analysis.
• Academic & Industrial Research: Serves as a starting material or model compound in organic chemistry research focused on steroid functionalization and protection/deprotection strategies.

Basic Information

Product Name	3α,6β-Bis[(Trimethylsilyl)Oxy]-5α-Cholestane
CAS No.	77828-33-2
Molecular Formula	C33H62O2Si2
Molecular Weight	547.0 g/mol
Synonyms	5α-Cholestane-3α,6β-diol bis(trimethylsilyl) ether; 3α,6β-Bis(trimethylsiloxy)-5α-cholestane; Cholestane-3α,6β-diol, bis(trimethylsilyl) ether; 5α-Cholestane-3α,6β-diyl bis(oxy)bis(trimethylsilane); TMS derivative of 5α-cholestane-3α,6β-diol
EINECS	Contact for details

Quality Control

Our 3α,6β-Bis[(Trimethylsilyl)Oxy]-5α-Cholestane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC and NMR, to ensure high chemical purity and structural identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.