Description

8-[(2S)-2-Hydroxy-3-Methyl-3-Butenyl]-5,7-Dimethoxy-2H-1-Benzopyran-2-One is a high-purity, optically active coumarin derivative with a defined stereochemistry. This compound serves as a critical intermediate or reference standard in advanced organic synthesis and analytical research. It is primarily needed by pharmaceutical R&D teams, specialty chemical manufacturers, and academic research institutions focused on bioactive natural product derivatives.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, particularly those with coumarin-based pharmacophores.
• Reference Standard: High-purity material for analytical method development, validation, and quality control in pharmaceutical and chemical laboratories.
• Natural Product Synthesis: Used in the total or semi-synthesis of complex natural products and their analogues for biological activity studies.
• Biochemical Research: Probe compound for investigating enzyme interactions, biological pathways, and structure-activity relationships (SAR).
• Fine Chemical Production: Intermediate in the manufacture of specialty chemicals, flavors, fragrances, and advanced materials.

Basic Information

Product Name	8-[(2S)-2-Hydroxy-3-Methyl-3-Butenyl]-5,7-Dimethoxy-2H-1-Benzopyran-2-One
CAS No.	77790-53-5
Molecular Formula	C₁₇H₂₀O₅
Molecular Weight	304.34 g/mol
Synonyms	(S)-5,7-Dimethoxy-8-(2-hydroxy-3-methylbut-3-en-1-yl)coumarin; 8-[(2S)-2-Hydroxy-3-methylbut-3-en-1-yl]-5,7-dimethoxy-2H-chromen-2-one; 5,7-Dimethoxy-8-(2-hydroxy-3-methyl-3-butenyl)coumarin (S-isomer); Demethylsuberosin (S-form); (S)-Demethylsuberosin; Auraptene precursor; Optically active coumarin derivative
EINECS	Contact for details

Quality Control

Our 8-[(2S)-2-Hydroxy-3-Methyl-3-Butenyl]-5,7-Dimethoxy-2H-1-Benzopyran-2-One is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and spectroscopic identification (NMR, IR, MS). Certificates of Analysis (COA) with detailed batch-specific results are provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.