Description

1-Bromomethyl-2,2-difluorocyclopropane is a versatile and highly functionalized cyclopropane derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromomethyl and difluorocyclopropane moieties, makes it an invaluable precursor for introducing fluorinated cyclopropane rings into target molecules, a key strategy in modern pharmaceutical and agrochemical research. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries to create novel compounds with enhanced biological activity and physical properties.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of fluorinated drug candidates, particularly in antiviral, anticancer, and CNS-active compounds.
• Agrochemical Synthesis: Used to construct fluorinated cyclopropane structures found in modern pesticides and herbicides, improving their metabolic stability and efficacy.
• Material Science Precursor: Employed in the development of specialty polymers and advanced materials where the difluorocyclopropane unit imparts specific chemical resistance or physical properties.
• Fluorine Chemistry Research: A fundamental reagent for studying cyclopropane ring-opening reactions and fluorine substitution effects in organic molecules.
• Ligand and Catalyst Development: Serves as a starting material for creating novel fluorinated ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Radiopharmaceutical Labeling: The bromine atom can be a potential site for radioisotope exchange (e.g., with Fluorine-18) for PET imaging agent development.

Basic Information

Product Name	1-Bromomethyl-2,2-Difluorocyclopropane
CAS No.	77613-65-1
Molecular Formula	C5H7BrF2
Molecular Weight	185.01 g/mol
Synonyms	(Bromomethyl)difluorocyclopropane; 2,2-Difluoro-1-(bromomethyl)cyclopropane; 1-(Bromomethyl)-2,2-difluorocyclopropane; Difluorocyclopropanemethyl bromide; Cyclopropane, 1-(bromomethyl)-2,2-difluoro-; Bromomethyl difluorocyclopropane
EINECS	Contact for details

Quality Control

Our 1-Bromomethyl-2,2-difluorocyclopropane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Assay (HPLC)	≥ 96.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.