Description

2-(Tetrahydro-Pyran-2-Yloxy)-Ethanethiol is a specialized organosulfur compound featuring a thiol group protected by a tetrahydropyranyl (THP) ether, making it a valuable intermediate in synthetic organic chemistry. This compound matters for its role as a protected thiol synthon, allowing for the controlled introduction of sulfur-containing functional groups in complex molecule assembly. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications in drug discovery, ligand synthesis, and polymer modification.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) containing thiol or disulfide linkages.
• Peptide Chemistry: Used in the preparation of cysteine analogs and for introducing protected thiol handles in solid-phase peptide synthesis (SPPS).
• Ligand Synthesis: Serves as a precursor for chelating agents and catalysts used in asymmetric synthesis and metal complexation.
• Polymer Modification: Employed to incorporate thiol functional groups into polymer backbones for creating cross-linkable or adhesive materials.
• Agrochemical Research: Intermediate in the development of novel fungicides, herbicides, and plant growth regulators.
• Chemical Biology Probes: Useful for labeling and bioconjugation strategies due to the reactivity of the masked thiol group.

Basic Information

Product Name	2-(Tetrahydro-Pyran-2-Yloxy)-Ethanethiol
CAS No.	77597-08-1
Molecular Formula	C7H14O2S
Molecular Weight	162.25 g/mol
Synonyms	2-(Tetrahydro-2H-pyran-2-yloxy)ethanethiol; 2-(THP-O)Ethanethiol; 2-(Tetrahydropyran-2-yloxy)ethanethiol; 2-(Oxan-2-yloxy)ethane-1-thiol; THP-protected 2-mercaptoethanol; 2-Mercaptoethyl tetrahydropyranyl ether; Ethanethiol, 2-[(tetrahydro-2H-pyran-2-yl)oxy]-; 2-[(Oxan-2-yl)oxy]ethanethiol
EINECS	Contact for details

Quality Control

Our 2-(Tetrahydro-Pyran-2-Yloxy)-Ethanethiol is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chromatography (HPLC, GC) and spectroscopic methods (NMR, IR), to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request. We are committed to meeting the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 15-25°C under an inert atmosphere (e.g., nitrogen or argon) due to its sensitivity to oxidation. Keep away from heat, sparks, and open flame. For long-term storage, consider refrigeration at 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.