Description

2-[2-[3-[(1,1-Dimethylethyl)Amino]-2-Hydroxypropoxy]Phenoxy]-n-Methylacetamide Monohydrochloride is a high-purity pharmaceutical intermediate and active ingredient. This compound is critical for the synthesis and development of advanced β-adrenergic blocking agents, offering precise pharmacological activity. It is primarily required by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical producers engaged in cardiovascular drug development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of β-blocker APIs (Active Pharmaceutical Ingredients).
• Cardiovascular Drug Research: Used in preclinical and clinical research for developing new antihypertensive and antiarrhythmic agents.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical labs.
• Process Chemistry: Employed in scale-up and optimization of manufacturing processes for final drug substances.
• Academic Research: Utilized in university and institutional studies investigating adrenergic receptor mechanisms and medicinal chemistry.

Basic Information

Product Name	2-[2-[3-[(1,1-Dimethylethyl)Amino]-2-Hydroxypropoxy]Phenoxy]-n-Methylacetamide Monohydrochloride
CAS No.	77590-95-5
Molecular Formula	C18H30N2O4 • HCl
Molecular Weight	374.90 g/mol
Synonyms	Bucindolol Hydrochloride; (±)-Bucindolol Hydrochloride; 1-[2-[2-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]phenoxy]ethyl]-3-methyl-2-imidazolidinone Hydrochloride; MJ 13105-1; MJ-13105-1; BUCINDOLOL HCL; UNII-8JQ5607IO5; Vancor
EINECS	Contact for details

Quality Control

Our 2-[2-[3-[(1,1-Dimethylethyl)Amino]-2-Hydroxypropoxy]Phenoxy]-n-Methylacetamide Monohydrochloride is manufactured under strict quality management systems. Each batch is tested to meet high-purity standards suitable for pharmaceutical research and development. Comprehensive testing includes identity, purity, and impurity profile analysis via HPLC, NMR, and MS. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to ensure traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.