Description

Benzyl (S)-(-)-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylate p-Toluenesulfonic Acid Salt is a high-purity, chiral organic salt of significant importance in advanced synthetic chemistry. This compound serves as a critical chiral building block and intermediate for the synthesis of complex pharmaceutical molecules and fine chemicals. It is essential for research and development in the pharmaceutical industry, particularly for creating active pharmaceutical ingredients (APIs) with specific stereochemistry. Our product is supplied to meet the stringent quality demands of process development and scale-up activities.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex APIs, especially for neurological and cardiovascular targets.
• Asymmetric Synthesis: Used as a chiral auxiliary or precursor in catalytic and stoichiometric asymmetric reactions to induce enantioselectivity.
• Process Chemistry: Employed in the development and optimization of scalable manufacturing routes for novel drug candidates.
• Medicinal Chemistry Research: A valuable scaffold for constructing compound libraries and exploring structure-activity relationships (SAR) in drug discovery.
• Fine Chemical Production: Utilized in the manufacture of specialty chemicals and advanced materials requiring high enantiomeric purity.
• Academic & Industrial R&D: Serves as a reference standard and starting material for synthetic methodology development in organic chemistry.

Basic Information

Product Name	Benzyl (S)-(-)-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylate p-Toluenesulfonic Acid Salt
CAS No.	77497-97-3
Molecular Formula	C24H25NO5S
Molecular Weight	439.52 g/mol
Synonyms	(S)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic Acid Benzyl Ester p-Toluenesulfonate; (S)-Benzyl 1,2,3,4-Tetrahydroisoquinoline-3-carboxylate Tosylate Salt; (S)-Benzyl 3,4-Dihydro-1H-isoquinoline-3-carboxylate 4-Methylbenzenesulfonic Acid Salt; (S)-Benzyl THIQ-3-carboxylate TsOH Salt; (S)-(-)-Benzyl 1,2,3,4-Tetrahydro-3-isoquinolinecarboxylate Tosic Acid Salt; Benzyl (S)-THIQ-3-CO2 TsOH; (S)-Benzyl 1,2,3,4-Tetrahydro-3-isoquinolinecarboxylate p-Toluenesulfonate
EINECS	Contact for details

Quality Control

Our Benzyl (S)-(-)-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylate p-Toluenesulfonic Acid Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and enantiomeric purity, meeting the exacting standards required for pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.