Description

(S)-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid T-Butyl Ester CAS NO 77497-74-6 is a high-purity chiral building block essential for advanced pharmaceutical synthesis. This compound is valued for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and other fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the synthesis of various therapeutic agents, including central nervous system (CNS) drugs and enzyme inhibitors.
• Asymmetric Synthesis: Used as a starting material or intermediate in stereoselective chemical reactions to introduce the (S)-configured tetrahydroisoquinoline scaffold.
• Peptidomimetics Research: Serves as a constrained amino acid analog in the design and development of novel peptide-like compounds for drug discovery.
• Agrochemical Development: Employed in the research and production of advanced, optically active pesticides and herbicides.
• Catalyst and Ligand Preparation: Utilized in the preparation of chiral catalysts and ligands for homogeneous catalysis.
• Academic and R&D Laboratories: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry research programs.

Basic Information

Product Name	(S)-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid T-Butyl Ester
CAS No.	77497-74-6
Molecular Formula	C₁₄H₁₉NO₂
Molecular Weight	233.31 g/mol
Synonyms	(S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid tert-butyl ester; (S)-Tert-butyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate; (S)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid 1,1-dimethylethyl ester; (S)-3-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline; (S)-Boc-Tic-OH; (S)-Boc-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid; (S)-N-Boc-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid
EINECS	Contact for details

Quality Control

Our (S)-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-purity standards suitable for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.