Description

4-Acetamidobenzene D4 Sulfonyl Chloride is a deuterated derivative of a key sulfonyl chloride intermediate, where four hydrogen atoms are replaced with deuterium. This deuteration is critical for enhancing metabolic stability and traceability in research applications, providing a valuable tool for analytical and synthetic chemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical and agrochemical industries for developing and studying novel compounds, particularly in the synthesis of deuterated drug candidates and as an internal standard in mass spectrometry.

Application

• Pharmaceutical Research & Development: As a deuterated building block for synthesizing isotopically labeled drug candidates to study pharmacokinetics, metabolism, and bioavailability (Deuterated Drug Discovery).
• Analytical Chemistry: Serving as a high-purity internal standard for quantitative analysis using Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS).
• Agrochemical Synthesis: Intermediate in the development of novel, isotopically labeled pesticides and herbicides for environmental fate and metabolic studies.
• Organic Synthesis: Key reagent for introducing the deuterated 4-acetamidobenzenesulfonyl moiety into more complex molecular architectures in research settings.
• Biochemistry & Proteomics: Potential use in chemical proteomics for creating activity-based probes or affinity tags with enhanced stability.

Basic Information

Product Name	4-Acetamidobenzene D4 Sulfonyl Chloride
CAS No.	77435-44-0
Molecular Formula	C8H4D4ClNO3S
Molecular Weight	~237.69 g/mol
Synonyms	N-(4-(Sulfonyl chloride-D4))acetamide; 4-Acetamidobenzenesulfonyl-D4 chloride; p-Acetamidobenzenesulfonyl-D4 chloride; Deuterated Sulfacetamide Chloride; [D4]-SAC; 4-(Acetylamino)benzenesulfonyl-D4 chloride; N-Acetyl-4-aminobenzenesulfonyl-D4 chloride; p-Acetylaminobenzenesulfonyl-D4 chloride
EINECS	Contact for details

Quality Control

Our 4-Acetamidobenzene D4 Sulfonyl Chloride is produced under strict quality management protocols to ensure high isotopic purity and chemical integrity, essential for sensitive analytical and synthetic applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity, isotopic enrichment (D-incorporation), and impurity profiles. We support research and development with reliable, batch-to-batch consistency and full traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity (D-incorporation)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.