Description

1-Methyl-D3-Pyrrolidine is a deuterated analog of N-methylpyrrolidine, featuring three deuterium atoms strategically incorporated into its methyl group. This isotopic labeling is critical for applications requiring enhanced molecular stability, reduced metabolic interference, or precise analytical tracking. It serves as a valuable building block and internal standard in advanced research and development. Key industries that utilize this compound include pharmaceutical development, agrochemical research, and analytical chemistry, particularly in mass spectrometry and NMR spectroscopy.

Application

• Pharmaceutical Research & Development: Used as a deuterated building block in the synthesis of isotopically labeled drug candidates for pharmacokinetic (PK), pharmacodynamic (PD), and metabolism (ADME) studies.
• Analytical Chemistry Standards: Serves as a high-purity internal standard for quantitative analysis via Gas Chromatography-Mass Spectrometry (GC-MS) and Liquid Chromatography-Mass Spectrometry (LC-MS), improving accuracy.
• Agrochemical Development: Employed in the synthesis of labeled pesticide or herbicide analogs to study environmental fate, degradation pathways, and residue analysis.
• Metabolomics & Biomarker Discovery: Acts as a stable isotope tracer in metabolic flux analysis to investigate biochemical pathways and identify disease biomarkers.
• Material Science Research: Utilized in the development of novel organic compounds and ligands where isotopic purity can influence physical or electronic properties.
• NMR Spectroscopy Solvent & Reagent: Functions as a deuterated solvent or shift reagent in nuclear magnetic resonance (NMR) spectroscopy due to its isotopic purity.

Basic Information

Product Name	1-Methyl-D3-Pyrrolidine
CAS No.	77422-30-1
Molecular Formula	C5H8D3N
Molecular Weight	88.16 g/mol
Synonyms	N-Methyl-d3-pyrrolidine; N-(Trideuteriomethyl)pyrrolidine; Pyrrolidine, 1-(trideuteriomethyl)-; 1-(Trideuteriomethyl)pyrrolidine; Deuterated N-Methylpyrrolidine; N-Methylpyrrolidine-d3; CD3-Pyrrolidine; Perdeuterated N-Methylpyrrolidine (common name for fully deuterated analog)
EINECS	Contact for details

Quality Control

Every batch of our 1-Methyl-D3-Pyrrolidine is manufactured and tested under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) that detail key parameters including isotopic purity (D-enrichment), chemical purity, and identity confirmation. Our quality commitment ensures the material meets the stringent requirements for research and analytical applications, supporting traceability and reproducibility in your work.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Due to its highly volatile and easily oxidized nature, the container should be kept tightly sealed at all times when not in use. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR / NMR)	Conforms to structure
Assay (GC / HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 99.0 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.