Description

Diethyl Malonate-13C2 is a stable isotope-labeled analog of diethyl malonate, where two carbon atoms are replaced with the carbon-13 isotope. This compound is essential for advanced analytical and synthetic chemistry, providing a non-radioactive tracer for precise metabolic studies, reaction mechanism elucidation, and quantitative analysis. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and analytical reagent industries who require high-fidelity internal standards for mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy.

Application

• Internal Standard for Quantitative Analysis: Serves as a critical reference standard in LC-MS and GC-MS for the accurate quantification of malonate derivatives and related compounds in complex matrices.
• Metabolic Pathway Tracing: Used in in vivo and in vitro studies to track the incorporation of malonate units in biosynthesis, such as in fatty acid and polyketide pathways.
• NMR Spectroscopy Studies: Provides distinct spectroscopic signatures for mechanistic studies in organic synthesis and structural analysis of reaction intermediates.
• Synthesis of Labeled Compounds: Acts as a key building block for the preparation of other carbon-13 labeled fine chemicals, active pharmaceutical ingredients (APIs), and advanced materials.
• Pharmaceutical R&D: Employed in drug discovery and development for pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) studies.
• Quality Control & Method Development: Used in analytical laboratories to develop, validate, and ensure the accuracy of chromatographic and spectroscopic methods.

Basic Information

Product Name	Diethyl Malonate-13C2
CAS No.	77386-82-4
Molecular Formula	C132C3H8O4 or C5H8O4 (with two 13C atoms)
Molecular Weight	~164.12 g/mol (for 13C2 labeled form)
Synonyms	Diethyl Malonate-13C2; Diethyl Propanedioate-13C2; Malonic Acid Diethyl Ester-13C2; Diethyl 13C2-Malonate; 1,3-Diethyl Propanedioate-13C2; DEM-13C2; Ethyl Malonate-13C2; Carbon-13 Labeled Diethyl Malonate
EINECS	Contact for details

Quality Control

Our Diethyl Malonate-13C2 is manufactured under controlled conditions to ensure exceptional isotopic and chemical purity. Each batch undergoes rigorous analysis, including isotopic enrichment verification by NMR and MS, chemical purity assessment by HPLC/GC, and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing isotopic purity, chemical assay, and impurity profile is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Isotopic Purity (13C2)	≥ 99 atom % 13C
Chemical Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Not applicable

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.