Description

Valproate Pivoxil is an ester prodrug of the established anticonvulsant and mood-stabilizing agent, valproic acid. This chemical modification is designed to enhance bioavailability and improve the pharmacokinetic profile for advanced pharmaceutical formulations. It is a critical intermediate for research and development chemists and manufacturers in the fine chemical and active pharmaceutical ingredient (API) sectors. The compound is primarily utilized in the synthesis of next-generation neurological and psychiatric therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of proprietary valproic acid prodrugs and related central nervous system (CNS) active compounds.
• Neurological Drug Research: Used in preclinical and clinical research for developing improved treatments for epilepsy, bipolar disorder, and migraine prophylaxis.
• Prodrug Development: Serves as a model compound in studies focusing on enhancing drug delivery, solubility, and metabolic stability through prodrug strategies.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling in API manufacturing.
• Process Chemistry: Utilized in scale-up and optimization of synthetic routes for valproate-based pharmaceuticals under current Good Manufacturing Practice (cGMP) guidelines.

Basic Information

Product Name	Valproate Pivoxil
CAS No.	77372-61-3
Molecular Formula	C16H30O4
Molecular Weight	286.41 g/mol
Synonyms	Valproate Pivoxil; Valproic Acid Pivoxil; Pivoxil Valproate; 2,2-Dimethylpropanoyloxymethyl Valproate; Valproate Pivoxil Hydrate (common form); Valproic Acid Pivaloyloxymethyl Ester; Pivaloyloxymethyl Valproate; VPA-PXM; Valpromide Pivoxil (related)
EINECS	Contact for details

Quality Control

Our Valproate Pivoxil is manufactured and tested to meet stringent quality standards suitable for pharmaceutical R&D and intermediate use. We employ advanced analytical techniques including HPLC, GC, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing specifications for assay, related substances, residual solvents, and other critical parameters. Our quality system supports compliance with relevant ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.