Description

n-Acetyl-D-Glucosamine-D3 is a stable isotope-labeled analog of N-acetylglucosamine, where three hydrogen atoms are replaced by deuterium. This compound is a critical tool in pharmaceutical and biomedical research, enabling precise metabolic tracing and quantification studies. It is primarily utilized by researchers and manufacturers in the fields of analytical chemistry, drug metabolism and pharmacokinetics (DMPK), and proteomics who require high-purity, isotopically labeled standards for mass spectrometry.

Application

• Internal Standard for LC-MS/MS: Serves as a quantitative internal standard in liquid chromatography-tandem mass spectrometry for the accurate measurement of endogenous N-acetylglucosamine and related metabolites.
• Drug Metabolism Studies (DMPK): Used in preclinical and clinical research to trace the metabolic pathways and pharmacokinetic profiles of glycosaminoglycan-based therapeutics.
• Biochemical Pathway Analysis: Enables the detailed study of the hexosamine biosynthetic pathway and O-GlcNAcylation processes in cell signaling and disease models.
• Proteomics and Glycomics Research: Facilitates the identification and quantification of glycoproteins and complex carbohydrates in biological samples.
• Diagnostic Assay Development: Employed in the development of high-sensitivity clinical diagnostic kits for metabolic disorders related to carbohydrate metabolism.

Basic Information

Product Name	n-Acetyl-D-Glucosamine-D3
CAS No.	77369-11-0
Molecular Formula	C8H12D3NO6
Molecular Weight	222.21 g/mol (for D3 isotopologue)
Synonyms	2-Acetamido-2-deoxy-D-glucose-D3; N-Acetyl-D-glucosamine-D3; GlcNAc-D3; 2-(Acetylamino)-2-deoxy-D-glucopyranose-D3; N-Acetylchitosamine-D3; NAG-D3; 2-Acetamido-2-deoxy-D-glucopyranose-D3; D-Glucose, 2-(acetylamino)-2-deoxy-, 1,2,6,6-d4- (labeled positions may vary)
EINECS	Contact for details

Quality Control

Our n-Acetyl-D-Glucosamine-D3 is manufactured under strict quality systems to ensure the high isotopic purity and chemical integrity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D-content), chemical purity, and analytical results. We support research and development with materials suitable for use under GMP and ISO 9001 guided frameworks, ensuring traceability and reliability for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.