Description

Nikkomycin J CAS NO 77368-59-3 is a potent nucleoside-peptide antibiotic belonging to the nikkomycin family, which acts as a competitive inhibitor of chitin synthase. This compound is of significant interest for its targeted antifungal activity, offering a specific mode of action against chitin-containing fungi. It is primarily utilized by researchers in pharmaceutical development, agricultural science, and microbiology for investigating novel antifungal agents and studying fungal cell wall biosynthesis.

Application

• Antifungal Research & Development: Serves as a key reference standard and active ingredient in the discovery and evaluation of new antifungal therapeutics.
• Agricultural Fungicide Studies: Used in research to assess efficacy against plant-pathogenic fungi, exploring its potential in crop protection.
• Biochemical Pathway Analysis: A critical tool for studying chitin synthase inhibition and understanding fungal cell wall construction in laboratory settings.
• Microbiology & Cell Biology: Employed in academic and industrial labs to investigate fungal growth, morphology, and the mechanisms of action of chitin synthesis inhibitors.
• Pharmaceutical Intermediates: Can be used as a building block or precursor in the synthesis of more complex antifungal compounds.

Basic Information

Product Name	Nikkomycin J
CAS No.	77368-59-3
Molecular Formula	C20H28N6O9
Molecular Weight	496.47 g/mol
Synonyms	Nikkomycin J; Nikko J; Antibiotic 68903 B; 5-[(2-Amino-4-hydroxy-4-oxobutanoyl)amino]-1-(5-carbamoyl-1,2,3,4-tetrahydro-2,4-dioxopyrimidin-1-yl)-1,5-dideoxy-β-D-allofuranuronic acid; Uridine-5'-carboxylic acid, 1,2,3,4-tetrahydro-1-[(1S,2R,3S,4S,5R)-2,3,4-trihydroxy-5-(hydroxymethyl)cyclopentyl]-2,4-dioxo-, 5-[(2-amino-1-hydroxy-2-oxoethylidene)amino]-, (1R)-; 68903 B
EINECS	Contact for details

Quality Control

Our Nikkomycin J is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.