Description

Isoquinoline, 1,2,3,4-Tetrahydro-6,7-Dimethoxy-1-[(4-Methoxyphenyl)Methyl]-, Hydrochloride (1:1) is a high-purity, complex organic salt with a defined molecular structure, serving as a critical advanced intermediate in pharmaceutical synthesis. Its value lies in providing a reliable and consistent building block for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular research. This compound is essential for pharmaceutical R&D laboratories and fine chemical manufacturers engaged in process development and scale-up activities.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and production of potential therapeutic agents, particularly for neurological and cardiovascular applications.
• Chemical Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of related pharmaceutical compounds.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and the design of new drug candidates targeting specific biological pathways.
• Process Chemistry Development: Employed in optimizing synthetic routes, studying reaction mechanisms, and scaling up production processes for complex molecules.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis and pharmacology.

Basic Information

Product Name	Isoquinoline, 1,2,3,4-Tetrahydro-6,7-Dimethoxy-1-[(4-Methoxyphenyl)Methyl]-, Hydrochloride (1:1)
CAS No.	77354-33-7
Molecular Formula	C19H23NO3·HCl
Molecular Weight	349.85 g/mol
Synonyms	1-[(4-Methoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride; 6,7-Dimethoxy-1-(4-methoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride; 1-(4-Methoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline HCl; Tetrahydroisoquinoline derivative hydrochloride; NSC 339539; (1,2,3,4-Tetrahydro-6,7-dimethoxy-1-isoquinolinyl)(4-methoxyphenyl)methanone hydrochloride (tautomeric form); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Isoquinoline derivative hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR). We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality commitment aligns with cGMP principles where applicable for pharmaceutical intermediate use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.