Description

4-Chloro-3-Trimethylsilanyl-Pyridine is a high-value organosilicon-protected pyridine derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in the trimethylsilyl (TMS) group, which acts as a versatile protecting group for the pyridine nitrogen, enabling selective functionalization and complex molecule construction. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting heterocyclic scaffolds.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where the chloropyridine moiety is a core structural element.
• Ligand & Catalyst Precursor: Serves as a starting material for synthesizing specialized nitrogen-containing ligands used in homogeneous catalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials requiring protected pyridine units.
• Custom Synthesis & Process Development: A versatile reagent for contract research organizations (CROs) and fine chemical manufacturers engaged in custom synthesis projects.
• Academic Research: Used in university and institutional labs for methodological development in organosilicon and heterocyclic chemistry.

Basic Information

Product Name	4-Chloro-3-Trimethylsilanyl-Pyridine
CAS No.	77332-85-5
Molecular Formula	C8H12ClNSi
Molecular Weight	185.72 g/mol
Synonyms	4-Chloro-3-(trimethylsilyl)pyridine; 3-Trimethylsilyl-4-chloropyridine; 4-Chloro-3-trimethylsilylpyridine; 4-Chloro-3-(trimethylsilanyl)pyridine; Pyridine, 4-chloro-3-(trimethylsilyl)-; 77332-85-5; 4-Chloro-3-TMS-pyridine
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-3-Trimethylsilanyl-Pyridine is produced and tested under strict quality management protocols to ensure consistency and reliability for your synthetic workflows. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with comprehensive identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing batch-specific results for purity, identity, and impurities are provided with each shipment. We support development and scale-up projects with the option for customized purity grades and analytical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.